Age-related changes in detection of spatial novelty

作者：Maa**erg David W; Shelley Laura E; Gilbert Paul E^*

来源：Behavioural Brain Research, 2012, 228(2): 447-451.

DOI：10.1016/j.bbr.2011.12.024

• Aging
• Spatial
• Object
• Novelty detection
• Exploration

Age-related changes in novelty detection for object-place associations was assessed in 6-mo and 25-mo-old Fisher 344/Brown Norway (F344/BN) rats. Old rats showed significant deficits compared to young rats in detecting spatial displacement of objects. The data suggest that object-place novelty detection is impaired in aged F344/BN rats using a rapidly acquired, exploratory-based task. The results may have important implications for the selection of efficient memory paradigms for future aging studies.

• 出版日期2012-3-17