Pulmonary changes induced by trans,trans-2,4-decadienal, a component of cooking oil fumes

作者：Wang C K; Chang L W; Chang H; Yang C H; Tsai M H; Tsai H T; Lin P^*

来源：European Respiratory Journal, 2010, 35(3): 667-675.

DOI：10.1183/09031936.00140508

• Bronchioloalveolar junctions
• cooking oil fumes
• lung adenocarcinoma
• signal transducer and activator of transcription 3
• trans,trans-2, 4-decadienal

Cooking oil fumes (COF) are known to be associated with respiratory diseases and risk of lung cancer. Involvement of trans,trans-2,4-decadienal (tt-DDE), a major component in COF, is suspected.
Male CD-1(R) (ICR) mice were intratracheally instilled with either 8 or 24 mg.kg(-1) tt-DDE weekly for 8 weeks. Total numbers and types of cells in bronchoalveolar lavage fluid (BALF), as well as pathological changes, and inflammatory gene modulations in the lung tissues were assessed.
We demonstrated that the number of alveolar macrophages in the BALF was significantly increased in tt-DDE-exposed animals. Histologically, there was a dose-correlated increase in epithelial hyperplasia and granulomatous nodules at the bronchioloalveolar junctions (BAJ). Although both Clara and alveolar type 11 cells were present in the BAJ lesion, only Clara cells were actively proliferative. However, only alveolar type 11 cells were found in the BAJ granulomatous nodules. Enhanced accumulation of phosphorylated signal transducer and activator of transcription 3 (pSTAT3), a known pro-carcinogenic factor, was also detected in many alveolar type 11 cells at the BAJ lesions.
As both BAJ hyperplasia and enhanced pSTAT3 accumulation are known risk factors associated with increased lung adenocarcinoma development, these findings suggest that tt-DDE may pose a risk in lung carcinogenesis.

• 出版日期2010-3