An Electroneutral Macrocyclic Iron(II) Complex That Enhances MRI Contrast in Vivo

作者：Touti Faycal; Singh Akhilesh Kumar; Maurin Philippe; Canaple Laurence; Beuf Olivier; Samarut Jacques; Hasserodt Jens^*

来源：Journal of Medicinal Chemistry, 2011, 54(12): 4274-4278.

DOI：10.1021/jm2002298

The first example of a macrocyclic ferrous complex, where two tetrazolyl pendent arms compensate the charge of the metal center, is synthesized and examined for its capacity to enhance MRI contrast in vitro and in vivo in the mouse.

• 出版日期2011-6-23