The lipopolysaccharide core of Actinobacillus suis and its relationship to those of Actinobacillus pleuropneumoniae

作者：Ganeshapillai Jeyabarathy; Boncheff Alexander G; Slavic Durda; MacInnes Janet; Monteiro Mario A^*

来源：Biochemistry and Cell Biology, 2011, 89(3): 351-358.

DOI：10.1139/O11-003

• Actinobacillus suis
• Actinobacillus pleuropneumoniae
• lipopolysaccharide
• core

The Gram-negative bacteria Actinobacillus suis colonizes the upper respiratory and genital tracts of swine. Along with capsular polysaccharides, lipopolysaccharides (O-chain -> core -> lipid A similar to cell) are a main cell-surface component of A. suis. In this study, we determined that A. suis lipopolysaccharide incorporates a conserved core that shares some structural features with several core types of A. pleuropneumoniae. These common core structural features likely account for the observed serological cross-reactivity between A. suis and A. pleuropneumoniae, and the data suggest that the structural epitopes responsible for immunogenicity are those in the outer core domain.

• 出版日期2011-6