Arterial and Venous Pulmonary Vascular Morphology and Their Relationship to Findings in Cardiac Magnetic Resonance Imaging in Smokers

作者：Rahaghi Farbod N^*; Wells J Michael; Come Carolyn E; De La Bruere Isaac A; Bhatt Surya P; Ross James C; Vegas Sanchez Ferrero Gonzalo; Diaz Alejandro A; Minhas Jasleen; Dransfield Mark T; Estepar Raul San Jose; Washko George R

来源：Journal of Computer Assisted Tomography, 2016, 40(6): 948-952.

DOI：10.1097/RCT.0000000000000465

• 3D reconstruction
• arterial
• cardiac magnetic resonance imaging
• chronic obstructive pulmonary disease
• computed tomography
• emphysema
• pulmonary vascular
• venous

Objective: Prior work has described the relationship between pulmonary vascular pruning on computed tomography (CT) scans and metrics of right-sided heart dysfunction in smokers. In this analysis, we sought to look at pruning on a lobar level, as well as examine the effect of the arterial and venous circulation on this association.
Methods: Automated vessel segmentation applied to noncontrast CT scans from the COPDGene Study in 24 subjects with cardiac magnetic resonance imaging scans was used to create a blood volume distribution profile. These vessels were then manually tracked to their origin and characterized as artery or vein.
Results: Assessment of pruning on a lobar level revealed associations between pruning and right ventricular function previously not observed on a global level. The right ventricular mass index, the right ventricular endsystolic volume index, and pulmonary arterial-to-aorta ratio were associated with both arterial and venous pruning, whereas right ventricular ejection fraction was associated with only arterial pruning.
Conclusions: Lobar assessment and segmentation of the parenchymal vasculature into arterial and venous components provide additional information about the relationship between loss of vasculature on CT scans and right ventricular dysfunction.

• 出版日期2016-12