Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer'

作者：Semkina Alevtina S; Abakumov Maxim A^*; Skorikov Alexander S; Abakumova Tatiana O; Melnikov Pavel A; Grinenko Nadejda F; Cherepanov Sergey A; Vishnevskiy Daniil A; Naumenko Victor A; Ionova Klavdiya P; Majouga Alexander G; Chekhonin Vladimir P

来源：Nanomedicine: Nanotechnology, Biology and Medicine , 2018, 14(5): 1733-1742.

DOI：10.1016/j.nano.2018.04.019

• magnetic nanoparticles
• drug delivery
• chemotherapy
• MRI-contrast agents
• breast adenocarcinoma
• iron oxide

In presented paper we have developed new system for cancer theranostics based on vascular endothelial growth factor (VEGF) targeted magnetic nanoparticles. Conjugation of anti-VEGF antibodies with bovine serum albumin coated PEGylated magnetic nanoparticles allows for improved binding with murine breast adenocarcinoma 4T1 cell line and facilitates doxorubicin delivery to tumor cells. It was shown that intravenous injection of doxorubicin loaded VEGF targeted nanoparticles increases median survival rate of mice bearing 4T1 tumors up to 50%. On the other hand magnetic resonance imaging (MRD of 4T1 tumors 24 h after intravenous injection showed accumulation of nanoparticles in tumors, thus allowing simultaneous cancer therapy and diagnostics.

• 出版日期2018-7