Neuroprotective labdane diterpenes from Fritillaria ebeiensis

作者：Xu Jing; Liu Cuizhou; Guo Ping; Guo Yuanqiang^*; Jin Da Qing; Song Xiaoqiang; Sun Zhanping; Gui Liping; Ma Yonggang

来源：Fitoterapia, 2011, 82(5): 772-776.

DOI：10.1016/j.fitote.2011.03.009

• Fritillaria ebeiensis
• Diterpene
• Labdane
• Neuroprotective effect

By bioactivity-guided isolation, two labdane diterpenes (1 and 2) have been isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated as 6 alpha,7 beta-dihydroxy-labda-8 (17),12(E),14-triene (1) and 6-oxo-2 alpha-hydroxy-labda-7,12(E), 14-triene (2), on the basis of spectroscopic data analysis (IR, ESI-MS, HR-ESI-MS, 1D and 2D NMR). Both of the isolates showed neuroprotective effects against MPP(+)-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.

• 出版日期2011-7
• 单位南开大学