Timing of antiretroviral therapy initiation after diagnosis of recent human immunodeficiency virus infection and CD4(+) T-cell recovery

作者：Ding Y; Duan S; Wu Z; Ye R; Yang Y; Yao S; Wang J; Xiang L; Jiang Y; Lu L; Jia M; Detels R; He N^*

来源：Clinical Microbiology and Infection, 2016, 22(3): 290.e5.

DOI：10.1016/j.cmi.2015.11.007

• Antiretroviral therapy
• CD4(+)T cells
• China
• human immunodeficiency virus
• immune recovery
• recent infection

We retrospectively examined the timing of antiretroviral therapy (ART) initiation and CD4(+) T-cell recovery over 36 months among recent human immunodeficiency virus (HIV) infections using BED (HIV-1 subtypes B, E and D) immunoglobulin G capture enzyme immunoassay (BED-CEIA). Regardless of baseline CD4(+) counts, individuals (n = 393) who initiated ART > 2 months after diagnosis had significantly decreased probability and rate of achieving CD4(+) counts >= 900 cells/>= L or >= 600 cells/>= L than those individuals (n = 135) who started ART earlier (>= 2 months). But the mean CD4(+) counts in two groups converged after 30 months of treatment. Early ART initiation leads to accelerated CD4(+) recovery, but does not offer a longterm advantage in CD4(+) counts.

• 出版日期2016-3
• 单位中国疾病预防控制中心性病艾滋病预防控制中心; 云南省疾病预防控制中心; 复旦大学