A Divergent Approach to the Diastereoselective Synthesis of Several Ant-Associated Iridoids

作者:Beckett Joel S; Beckett James D; Hofferberth John E*
来源:Organic Letters, 2010, 12(7): 1408-1411.
DOI:10.1021/ol100077z

摘要

The ant-associated iridoids nepetalactol, actinidine, dolichodial, isoiridomyrmecin, and dihydronepetalactone were prepared from citronellal using a divergent approach. Key features include a three-step synthesis of the Individual antipodes of actinidine by a novel tandem cycloaddition/pyridine formation and a facile diastereoselective synthesis of both enantiomers of dolichodial.

  • 出版日期2010-4-2