Altered expression and function of ryanodine receptors and FKBP12.6 after subarachnoid hemorrhage: more than meets the eye

作者：Jackson William F^*

来源：Journal of Cerebral Blood Flow and Metabolism, 2011, 31(1): 1-2.

DOI：10.1038/jcbfm.2010.182

• FKBP12.6
• immunophilins
• myogenic tone
• ryanodine receptors
• vascular smooth muscle

Subarachnoid hemorrhage decreases the expression of ryanodine receptors and increases the expression of the immunophilin, FK506-binding protein (FKBP)12.6 in cerebrovascular smooth muscle cells, reducing the occurrence of Ca2+ sparks, limiting negative feedback regulation of cerebrovascular tone and promoting vasospasm. However, given the large number of binding partners with which FKBP12.6 and related proteins interact, it appears likely that the altered expression of this immunophilin will have a broader impact on cerebrovascular smooth muscle function. In addition, the mechanisms responsible for the measured changes in expression of ryanodine receptors and FKBP12.6 yet remain unknown. These topics should prove to be fertile ground for future studies. Journal of Cerebral Blood Flow & Metabolism (2011) 31, 1-2; doi:10.1038/jcbfm.2010.182; published online 13 October 2010

• 出版日期2011-1