Cerebral glucose metabolism: Influence on perihematomal edema formation after intracerebral hemorrhage in cat models

作者：Lin Xiangtao; Tang Yuchun; Sun Bo; Hou Zhongyu; Meng Haiwei; Li Zhenping; Liu Qingwei; Liu Shuwei^*

来源：Acta Radiologica, 2010, 51(5): 549-554.

DOI：10.3109/02841851003660065

• Glucose metabolism
• perihematomal edema
• intracerebral hematoma
• MRI
• FDG
• PET/CT
• cat

Background: Most intracerebral hemorrhage (ICH) imaging studies focus on structural brain changes. Stereotactic neuroimaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT) are helpful in the diagnosis of ICH, monitoring the subsequent recovery and investigating its functional mechanisms.
Purpose: To explore the influence of the changes in cerebral glucose metabolism on perihematomal edema formation in an experimental cat model of ICH.
Material and Methods: Forty-eight cats were divided into 1 sham operation group (6 cats) and 7 ICH model groups (42 cats)". The ICH model groups were injected with 1.0 ml autologous nonheparinized blood into their thalami using accurate stereotactic guidance apparatus. MRI and (18)F-fluorodeoxyglucose (FDG) PET/CT scans were acquired at 2, 6, 12, 24, 48, 72, and 120 h following the intervention. Pearson's correlation test was used to evaluate the association between T2-weighted signal intensity and the edema volume. Student's t test and q test were used to identify the times of significant temporal changes.
Results: The volume of perilesional edema did not significantly increase from 2 h to 12 h after ICH, but then increased by 229.4% at 24 h, peaked (by 273.5%), and steadily decreased by 72 h. The FDG intensity in perihematomal edema tissues was markedly reduced 2 h after ICH on PET images, reached its lowest level at 12 h, and then steadily increased at 24 h and 48 h. The changes of standard absorption value (SUV) in perihematomal edema were consistent with those of FDG intensity.
Conclusion: Perihematomal glucose metabolism abnormalities have a close relationship with the formation of vasogenic edema. Furthermore, abnormal glucose metabolism may impair capillary integrity and increase blood-brain barrier permeability.

• 出版日期2010-6
• 单位山东省医学影像学研究所; 山东大学