Determinants of Vitamin D Status in Caucasian Adults: Influence of Sun Exposure, Dietary Intake, Sociodemographic, Lifestyle, Anthropometric, and Genetic Factors

作者：Touvier Mathilde^*; Deschasaux Melanie; Montourcy Marion; Sutton Angela; Charnaux Nathalie; Kesse Guyot Emmanuelle; Assmann Karen E; Fezeu Leopold; Latino Martel Paule; Druesne Pecollo Nathalie; Guinot Christiane; Latreille Julie; Malvy Denis; Galan Pilar; Hercberg Serge; Le Clerc Sigrid; Souberbielle Jean Claude; Ezzedine Khaled

来源：Journal of Investigative Dermatology, 2015, 135(2): 378-388.

DOI：10.1038/jid.2014.400

Very few studies have investigated the determinants of serum vitamin D levels using a set of variables that include simultaneously sun exposure, phototype, dietary intake, sociodemographics, anthropometric, lifestyle data, and genetic polymorphisms. Our objective was to investigate the associations between all these parameters and vitamin D status in a large sample of French adults. This cross-sectional survey was based on 1,828 middle-aged Caucasian adults from the SU.VI.MAX (SUpplementation en Vltamines et Mineraux AntioXydants) study. Plasma 25-hydroxyvitamin D (25OHD) concentration was lower among women (P<0.0001), older subjects (P=0.04), obese/underweight (P<0.0001), those living at higher latitudes (P<0.0001), those whose blood draw occurred in early spring (P<0.0001), less physically active (P<0.0001), with low sun exposure (P<0.0001), and with no-to-low alcohol intake (P=0.0001). Mutant GC rs4588 and rs7041 single nucleotide polymorphisms were associated with lower and higher 250HD concentrations, respectively (P<0.0001). Dietary intake was not a major determinant of vitamin D status (P=0.7). This study provides an overall picture of determinants of vitamin D status. Several modifiable factors were identified, such as daily-life moderate sun exposure, physical activity, and normal-weight maintenance, which should be targeted by public health policies in order to improve vitamin D status in the general population, while avoiding active/intensive sun exposure, in line with recommendations for skin cancer prevention.

• 出版日期2015-2