Atypical PKC iota as Target for Glioblastoma Therapy iota

作者：Lorimer Ian A J^*

来源：Current Cancer Drug Targets, 2015, 15(2): 136-144.

• Atypical protein kinase C
• glioblastoma
• glioma
• PKC iota
• PKC zeta
• PTEN

Glioblastoma (grade IV astrocytoma) is an aggressive and incurable form of brain tumor. It invariably shows extensive invasion at the time of diagnosis, often involving both hemispheres. Recent studies have given us a very detailed picture of glioblastoma genetics. These paint a picture of a disease with extensive heterogeneity, both between patients and within individual patients. This within patient heterogeneity presents a major challenge in the design of targeted therapies. One approach is to identify targets that are common downstream elements in signaling pathways that are aberrantly activated in glioblastoma. Here we review the evidence that the atypical protein kinase C family member PKC iota. may fulfill this role. Our current understanding of PKC iota. activation mechanisms is discussed and related to common genetic changes in glioblastoma. The data showing an essential role for PKC iota. in multiple aspects of glioblastoma pathology are also reviewed. Finally, data on the role of PKC iota. in normal brain function are reviewed for insights into potential side effects of PKC iota. inhibition in the central nervous system.

• 出版日期2015