Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case-control study

作者：Schoof N; von Bonin F; Koenig I R; Moessner R; Krueger U; Reich K; Berking C; Volkenandt M; Ziegler A; Boeckmann L; Kuschal C; Thoms K M; Kube D^*; Emmert S

来源：Genes and Immunity, 2009, 10(6): 586-590.

DOI：10.1038/gene.2009.40

• cutaneous melanoma
• interleukin-10
• cytokines
• gene polymorphisms
• risk factor

Inherited promoter polymorphisms of the interleukin (IL)-10 gene resulting in altered IL-10 production may contribute to a genetic susceptibility for melanoma. We investigated the role of a haplotype from distal as well as proximal polymorphic sites [-7400InDel, -6752AT (rs6676671), -3538AT (rs1800890), -1087AG (rs1800896), -597AC (rs1800872)] of the IL-10 5'-flanking region in a hospital-based case-control study of 165 Caucasian patients with cutaneous melanoma from Germany in comparison with 162 healthy cancer-free Caucasian control participants from the same area matched by age. Using multivariate analysis for the number of nevi and skin type, the IL-10 'higher producing' haplotype ITAGC was found to be significantly associated with a reduced risk of developing melanoma ( adjusted P = 0.02). Although our findings need to be confirmed by independent and larger multicenter studies, we have described for the first time the association of distal gene variants of the IL-10 gene as an independent risk factor for melanoma. Genes and Immunity ( 2009) 10, 586-590; doi:10.1038/gene.2009.40; published online 21 May 2009

• 出版日期2009-9
• 单位河北医科大学