Dynamic and biocompatible thermo-responsive magnetic hydrogels that respond to an alternating magnetic field

作者：Crippa Federica; Moore Thomas L; Mortato Mariangela; Geers Christoph; Haeni Laetitia; Hirt Ann M; Rothen Rutishauser Barbara; Petri Fink Alke^*

来源：Journal of Magnetism and Magnetic Materials, 2017, 427: 212-219.

DOI：10.1016/j.jmmm.2016.11.023

• Magnetic hydrogels
• Magnetic nanoparticles
• Hyperthermia
• Stimuli-responsive substrates
• Mechanobiology

Magnetic thermo-responsive hydrogels are a new class of materials that have recently attracted interest in biomedicine due to their ability to change phase upon magnetic stimulation. They have been used for drug release, magnetic hyperthermia treatment, and can potentially be engineered as stimuli-responsive substrates for cell mechanobiology. In this regard, we propose a series of magnetic thermo-responsive nanocomposite substrates that undergo cyclical swelling and de-swelling phases when actuated by an alternating magnetic field in aqueous environment. The synthetized substrates are obtained with a facile and reproducible method from poly-N-isopropylacrylamide and superparamagnetic iron oxide nanoparticles. Their conformation and the temperature-related, magnetic, and biological behaviors were characterized via scanning electron microscopy, swelling ratio analysis, vibrating sample magnetometry, alternating magnetic field stimulation and indirect viability assays. The nanocomposites showed no cytotoxicity with fibroblast cells, and exhibited swelling/deswelling behavior near physiological temperatures (around 34 degrees C). Therefore these magnetic thermo-responsive hydrogels are promising materials as stimuli-responsive substrates allowing the study of cell-behavior by changing the hydrogel properties in situ.

• 出版日期2017-4-1