Direct Transformation of Amides into alpha-Amino Phosphonates via a Reductive Phosphination Process

作者:Gao Yuzhen; Huang Zhongbin; Zhuang Rongqiang; Xu Jian; Zhang Pengbo; Tang Guo*; Zhao Yufen
来源:Organic Letters, 2013, 15(16): 4214-4217.
DOI:10.1021/ol4019419

摘要

The first general method for the reductive phosphination of amides in one pot has been developed. The reactions described provide a novel access to alpha-amino phosphonates in good to excellent yields, cover a broad scope of substrates such as secondary and tertiary amides, and do not require a low temperature.