NF-kappa B inhibitors for the treatment of inflammatory diseases and cancer

作者：Calzado Marco A; Bacher Susanne; Schmitz M Lienhard^*

来源：Current Medicinal Chemistry, 2007, 14(3): 367-376.

DOI：10.2174/092986707779941113

• inflammation
• cancer
• NF-kappa B
• inhibitor
• I kappa B
• IKK
• transcription factor

The NF-kappa B/Rel signaling system is a paradigm for gene activation in response to inflammatory and menacing stimuli. Given the growing body of evidence showing an important involvement of NF-kappa B for the onset of autoimmune diseases and different types of cancer, NF-kappa B is an important drug target for the adjuvant therapy of these diseases. Great efforts have been made for the development of highly specific NF-kappa B inhibitors, some of them being currently tested in phase II clinical trials. Here we discuss recent progress in the identification of druggable components of the NF-kappa B signaling system and the development and potential use of novel NF-kappa B inhibitors.

• 出版日期2007