A selective and sensitive fluorescent albumin probe for the determination of urinary albumin

作者:Wu Ying Yi; Yu Wan Ting; Hou Tai Cheng; Liu Tao Kai; Huang Chi Ling; Chen I Chia; Tan Kui Thong*
来源:Chemical communications, 2014, 50(78): 11507-11510.
DOI:10.1039/c4cc04236k

摘要

In this communication, we report a simple albumin probe based on a fluorescent molecular rotor for the detection of trace albumin levels in urine. In the presence of albumin, the probe exhibits remarkable 400-fold fluorescence enhancement with high selectivity and sensitivity. The probe was successfully applied in the quantitative detection of urinary albumin.