Audioprofile Surfaces: The 21st Century Audiogram

作者：Taylor Kyle R; Booth Kevin T; Azaiez Hela; Sloan Christina M; Kolbe Diana L; Glanz Emily N; Shearer A Eliot; DeLuca Adam P; Anand V Nikhil; Hildebrand Michael S; Simpson Allen C; Eppsteiner Robert W; Scheetz Todd E; Braun Terry A; Huygen Patrick L M; Smith Richard J H^*; Casavant Thomas L^*

来源：Annals of Otology Rhinology and Laryngology, 2016, 125(5): 361-368.

DOI：10.1177/0003489415614863

• audiometric data
• audioprofile surfaces
• audiograms
• hearing loss

Objective:
To present audiometric data in 3 dimensions by considering age as an addition dimension.
Methods:
Audioprofile surfaces (APSs) were fitted to a set of audiograms by plotting each measurement of an audiogram as an independent point in 3 dimensions with the x, y, and z axes representing frequency, hearing loss in dB, and age, respectively.
Results:
Using the Java-based APS viewer as a standalone application, APSs were pre-computed for 34 loci. By selecting APSs for the appropriate genetic locus, a clinician can compare this APS-generated average surface to a specific patient's audiogram.
Conclusion:
Audioprofile surfaces provide an easily interpreted visual representation of a person's hearing acuity relative to others with the same genetic cause of hearing loss. Audioprofile surfaces will support the generation and testing of sophisticated hypotheses to further refine our understanding of the biology of hearing.

• 出版日期2016-5
• 单位上海生物信息技术研究中心