A facilely synthesized amino-functionalized metal-organic framework for highly specific and efficient enrichment of glycopeptides

作者：Zhang, Yi-Wei; Li, Ze; Zhao, Qiang; Zhou, Ying-Lin; Liu, Hu-Wei; Zhang, Xin-Xiang^*

来源：Chemical communications, 2014, 50(78): 11504-11506.

DOI：10.1039/c4cc05179c

• HYDROPHILIC INTERACTION CHROMATOGRAPHY
• SELECTIVE ENRICHMENT
• MAGNETIC NANOPARTICLES
• MASS-SPECTROMETRY
• CLICK MALTOSE
• SEPARATION
• GLYCANS
• PHASE
• GLYCOSYLATION
• HEMAGGLUTININ

A facilely synthesized amino-functionalized metal-organic framework (MOF) MIL-101(Cr)-NH2 was first applied for highly specific glycopeptide enrichment based on the hydrophilic interactions. With the special characteristics of the MOF, the material performed well in selectivity and sensitivity for both standard glycoprotein samples and complex biological samples.

• 出版日期2014
• 单位北京大学