Granulocyte Colony-Stimulating Factor-Producing Gallbladder Cancer

作者：Kanaya Nobuhiko^*; Aoki Hideki; Yamasaki Rie; Morihiro Toshiaki; Takeuchi Hitoshi

来源：Acta Medica Okayama, 2016, 70(5): 393-396.

• gallbladder cancer
• G-CSF
• unidentified fever
• leukocystosis
• adenocarcinoma

We report a case of a granulocyte colony-stimulating factor (G-CSF)-producing gallbladder tumor associated with fever in a middle-aged female. Preoperative blood analysis showed leukocytosis with elevated levels of C-reactive protein and G-CSF. We resected the liver at S4a+S5, with regional lymph node dissection and partial resection of the duodenum. Histology revealed undifferentiated carcinoma with spindle and giant cells and papillary adenocarcinoma. Immunohistochemistry revealed Stage IIIB G-CSF-producing gallbladder cancer. Postoperatively, leukocyte and serum G-CSF levels decreased to within normal limits. Adjuvant gemcitabine chemotherapy was administered for 16 months, and she has been recurrence-free for 48 months.

• 出版日期2016-10