A potent alpha-glucosidase inhibitor from Myristica cinnamomea King

作者：Sivasothy Yasodha; Yong Loo Kong; Hoong Leong Kok; Litaudon Marc; Awang Khalijah^*

来源：Phytochemistry, 2016, 122: 265-269.

DOI：10.1016/j.phytochem.2015.12.007

• Myristica cinnamomea King
• Myristicaceae
• Dimeric acylphenol
• Acylphenol
• Giganteone D
• Cinnamomeone A
• alpha-Glucosidase inhibitor

A dimeric acylphenol and a potent alpha-glucosidase inhibitor, giganteone D (IC50 5.05 mu M), was isolated and characterized from the bark of Myristica cinnamomea King. The bark also yielded an acylphenol with an unprecedented skeleton for which the name cinnamomeone A (IC50 358.80 mu M) was proposed. Their structures were established by means of NMR and MS spectrometric analyses. The Lineweaver-Burk plot of giganteone D indicated that it was a mixed -type inhibitor. This is the first report on the alpha-glucosidase inhibiting potential of acylphenols.

• 出版日期2016-2