Phosphoinositide 3-kinase inhibition enables retinoic acid-induced neurogenesis in monolayer culture of embryonic stem cells

作者：Kotasova Hana; Vesela Iva; Kucera Jan; Houdek Zbynek; Prochazkova Jirina; Kralickova Milena; Pachernik Jiri^*

来源：Journal of Cellular Biochemistry, 2012, 113(2): 563-570.

DOI：10.1002/jcb.23380

• EMBRYONIC STEM CELL
• RETIONIC ACID
• NEUROGENESIS
• DIFFERENTIATION

Retinoic acid (RA) is able to induce the differentiation of embryonic stem cells into neuronal lineages. The mechanism of this effect is unknown but it has been evidenced to be dependent on the formation of floating spheroids called embryoid bodies. Results presented here show that the inhibition of phosphoinositide 3-kinase signaling pre-determines mouse embryonic stem cells to RA induced neurogenesis in monolayer culture with no need of embryoid bodies formation. J. Cell. Biochem. 113: 563570, 2012.

• 出版日期2012-2