科研之友
微信
新浪微博
Facebook
分享链接
摘要
Developments and mechanism of the first generation Dutch resolution, the second generation Dutch resolution and reverse Dutch resolution are reviewed. Diastereomeric crystallization can be formed easily and rapidly with high yield and nearly 100% ee in Dutch resolution. Members of the family resolving agents show the solid solution behavior in the first generation Dutch resolution. In the second generation Dutch resolution, nucleation inhibitor widens the metastable zone of diastereoisomers, and the nucleation temperature of the more soluble diastereomeric salt drops more than that of the less soluble diastereomeric salt. So the less soluble diastereomeric salt can crystallize easily. The application and outlook of Dutch resolution are presented in the end of this paper.
- 出版日期2007-11
- 单位河北科技大学
