A Synthetic Method to Access Symmetric and Non-Symmetric 2-(N,N '-disubstituted)guanidinebenzothiazoles

作者：Cruz Alejandro^*; Padilla Martinez Itzia I; Garcia Baez Efren V

来源：Molecules, 2012, 17(9): 10178-10191.

DOI：10.3390/molecules170910178

• 2-aminobenzothiazole
• dithiomethylcarboimidate
• isothiourea
• benzothiazole
• guanidine

Symmetric and non-symmetric 2-(N-H, N-methyl, N-ethylenyl and N-aryl)guanidinebenzothiazoles were synthesized from the reaction of ammonia, methylamine, pyrrolidine and aniline with dimethyl benzo[d]thiazol-2-yl-carbonodithioimidate (5) as intermediate. The products were characterized by H-1-, C-13-NMR spectroscopy and three of them by X-ray diffraction analysis. HN-phenyl protons formed intramolecular hydrogen bonds that assist the stereochemistry of the second substituent, whereas the HN-alkyl protons were involved in intermolecular hydrogen bonding.

• 出版日期2012-9