科研之友
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摘要
Organocatalysis: A modified Feist-Be´nary reaction employing acyclic β-ketoesters as the dinucleophile and (E)-β,β-bromo nitrostyrenes as the dielectrophile was developed for the asymmetric synthesis of 2,3-dihydrofurans. L-Threonine-derived tertiary amine/thiourea catalysts were found to be the most efficient catalysts, inducing the reaction in a highly enantioselective manner (see scheme; TBDPS=tert-butyldiphenylsilyl).
- 出版日期2012-10
