Angiotensin II induces type I collagen gene expression in human dermal fibroblasts through an AP-1/TGF-beta 1-dependent pathway

作者：Tang Hong Tai; Cheng Da Sheng; Jia Yi Tao; Ben Dao Feng; Ma Bing; Lv Kai Yang; Wei Duo; Sheng Zhi Yong; Xia Zhao Fan^*

来源：Biochemical and Biophysical Research Communications, 2009, 385(3): 418-423.

DOI：10.1016/j.bbrc.2009.05.081

• Angiotensin II
• Dermal fibroblasts
• Collagen
• Transforming growth factor-beta 1
• Activator protein-1

Angiotensin II is critically involved in skin Wound healing, but the underlying mechanism remains unclear. This study investigated the effect of angiotensin If on type I collagen gene activation in human dermal fibroblasts and the possible mechanism involved. Angiotensin II stimulated the mRNA and protein expression of type I collagen and TGF-beta 1. Effects were abolished by the angiotensin AT1 receptor antagonist ZD7155 but not by the AT2 blocker PD123319. Blockade of TGF-beta 1 markedly inhibited angiotensin II-induced type I collagen gene expression. Activator protein-1 (AP-1) decoy ODNs transfection suppressed angiotensin II-induced TGF-beta 1 expression, and also, diminished type I collagen expression. These data indicated that angiortensin II induces collagen gene activation in human dermal fibroblasts through an AT1-mediated AP-1/TGF-beta 1 signaling pathway.

• 出版日期2009-7-31
• 单位中国人民解放军总医院; 中国人民解放军第二军医大学