Association Study of Developmental Dyslexia Candidate Genes DCDC2 and KIAA0319 in Chinese Population

作者：Sun, Yimin^*; Gao, Yong; Zhou, Yuxi; Chen, Huan; Wang, Guoqing; Xu, Junquan; Xia, Jiguang; Huen, Michael S. Y.; Siok, Wai Ting; Jiang, Yuyang; Tan, Li Hai

来源：American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 2014, 165(8): 627-634.

DOI：10.1002/ajmg.b.32267

• developmental dyslexia
• DCDC2
• KIAA0319
• single nucleotide polymorphism
• association study

Developmental dyslexia (DD) is characterized by difficulties in reading and spelling independent of intelligence, educational backgrounds and neurological injuries. Increasing evidences supported DD as a complex genetic disorder and identified four DD candidate genes namely DYX1C1, DCDC2, KIAA0319 and ROBO1. As such, DCDC2 and KIAA0319 are located in DYX2, one of the most studied DD susceptibility loci. However, association of these two genes with DD was inconclusive across different populations. Given the linguistic and genetic differences between Chinese and other populations, it is worthwhile to investigate association of DCDC2 and KIAA0319 with Chinese dyslexic children. Here, we selected 60 tag SNPs covering DCDC2 and KIAA0319 followed by high density genotyping in a large unrelated Chinese cohort with 502 dyslexic cases and 522 healthy controls. Several SNPs (P-min=0.0192) of DCDC2 and KIAA0319 as well as a four-maker haplotype (P-adjusted=0.0289, Odds Ratio (OR) =1.3400) of KIAA0319 showed nominal association with DD. However, none of these results survived Bonferroni correction for multiple comparisons. Thus, the association of DCDC2 and KIAA0319 with DD in Chinese population should be further validated and their contribution to DD etiology and pathology should be interpreted with caution.

• 出版日期2014-12
• 单位清华大学; 深圳大学; 脑与认知科学国家重点实验室; 清华大学深圳研究生院; 香港中文大学; 中国人民解放军第二军医大学