UV-assisted grafting of polymers: A method towards biocompatible carbon nanotubes

作者：Petrov Petar^*; Georgiev Georgi; Momekova Denica; Momekov Georgi; Tsvetanov Christo B

来源：Polymer, 2010, 51(12): 2465-2471.

DOI：10.1016/j.polymer.2010.04.033

• Carbon nanotubes
• Biocompatible polymers
• UV irradiation

A strategy for covalent grafting of biocompatible polymers onto sidewalls of multi-walled carbon nanotubes (MWNTs) via UV-initiated free-radical polymerization is presented. The effects of the irradiation doze(time) and monomer/MWNTs ratio on the stability of the corresponding aqueous dispersions were investigated. It was found that stable dispersions of MWNTs modified with polyacrylamide, poly(N-isopropylacrylamide), poly[poly(ethylene glycol) methacrylatel and poly(sodium methacrylate) can be obtained by irradiation with UV light for at least 5 min at an irradiation dose rate of 5.7 J/cm(2) min at a minimum monomer/CNTs ratio of 200:1. Biocompatibility of polymer-modified MWNTs was assessed using the standard MTT-dye reduction assay and compared to pristine MWNTs. As a rule, all polymer-functionalized nanotubes examined in this study were non-cytotoxic up to concentration 150 mu g/mL and, remarkably, MWNTs-g-PNIPAAm did not exhibit cytotoxicity even at the highest concentration studied (300 mu g/mL). MWNTs modified with stimuli-sensitive polymers underwent a reversible transition from well-dispersed nanotubes in water to precipitate triggered by changes in temperature or pH.

• 出版日期2010-5-28