Neuropharmacological screening of essential oil from oleo gum resin of Gardenia lucida Roxb

作者：Shareef Mohammad Zubair; Yellu Narsimha Reddy^*; Achanta Venkata Narsimha Appa Rao

来源：Journal of Ethnopharmacology, 2013, 149(3): 621-625.

DOI：10.1016/j.jep.2013.07.004

• Gardenia lucida
• Rubiaceae
• Essential oil
• Anticonvulsant activity
• CNS depressant activity

Ethnopharmacological relevance: The oleo gum resin of Gardenia lucida is commonly employed in traditional medicine to treat multiple ailments, including epilepsy and mania. The essential oil isolated from it was screened for CNS activities to check if it is responsible for the claims made regarding the traditional use of the oleo gum resin.
Materials and methods: The hypnotic and anticonvulsant activity was assessed by pentobarbitone induced hypnosis and convulsant models Maximum electroshock (MES) and Pentylene tetrazole (PTZ) respectively. Effect on motor activity was evaluated using an actophotometer, rotarod and grip strength methods.
Results: The oil significantly potentiated the barbitone induced hypnosis and offered significant protection against the intensity and frequency of convulsions and mortality rate in both the convulsant models. A significant decrease in locomotion, motor impairment and loss of gripping reflex was also observed.
Conclusion: The essential oil of the oleo gum resin of Gardenia lucida is a CNS depressant and anticonvulsant with central muscle relaxant properties. This justifies the claims made regarding the use of the oleo gum resin of Gardenia lucida in CNS disorders.

• 出版日期2013-10-7