Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing

作者：Sun, Rongju; Chen, Wei; Zhao, Xiaodong; Li, Tanshi; Song, Qing^*

来源：Cell Biochemistry and Function, 2011, 29(8): 636-640.

DOI：10.1002/cbf.1799

• acheron
• inhibitor of differentiation (Id1)
• endothelial proliferation
• angiogenesis
• trauma

RNA binding protein acheron has proved to be either the mediator of integrin-extracellular matrix interactions or the regulatory factor that participates in vertebrate development, cell differentiation and cell death. We report the role of acheron in vascular endothelial proliferation, angiogenesis and wound healing post-trauma. Co-immunoprecipitation showed that Acheron forms a ternary complex with beta 1 integrin and Id1 in human umbilical vein endothelial cells following stimulation with serious trauma serum. Acheron, vascular endothelial growth factor (VEGF), and beta 1 integrin mRNA expression was apparently inhibited, and capillary density and wound healing rate also were reduced in Id1-deficient mice trauma model. Acheron together with Id1 significantly induces VEGF, not CD105 level inhibition by serious trauma serum for 24?h. In conclusion, we have demonstrated that acheron may be an effective mediator of promoting endothelial proliferation, angiogenesis and wound healing probably by regulating VEGF together with Id1.

• 出版日期2011-12
• 单位中国人民解放军总医院