Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features

作者：de Oliveira Jaqueline Carvalho; Scrideli Carlos Alberto^*; Brassesco Maria Sol; Morales Andressa Gois; Pezuk Julia Alejandra; Queiroz Rosane de Paula; Yunes Jose Andres; Brandalise Silvia Regina; Tone Luiz Gonzaga

来源：Leukemia Research, 2012, 36(3): 293-298.

DOI：10.1016/j.leukres.2011.10.005

• MicroRNA
• Pediatric acute lymphoblastic leukemia
• Prognostic features

The present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of childhood acute lymphoblastic leukemia (ALL) by quantitative real-time PCR. A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL. These findings suggest a potential activity of these microRNAs in pediatric ALL biology.

• 出版日期2012-3