A study on indices of apixaban anticoagulation: A single-center prospective study

作者：Komiyama Maki^*; Miyazaki Yusuke; Wada Hiromichi; Iguchi Moritake; Abe Mitsuru; Ogawa Hisashi; Akao Masaharu; Yamakage Hajime; Satoh Asahara Noriko; Sunagawa Yoichi; Morimoto Tatsuya; Hasegawa Koji

来源：Journal of Pharmacological Sciences, 2018, 137(2): 105-109.

DOI：10.1016/j.jphs.2018.05.001

• Atrial fibrillation
• New oral anticoagulants
• Apixaban
• Drug monitoring

Background: Depending on the characteristics of patients, the blood concentration of apixaban can unexpectedly increase, possibly leading to bleeding events. Anti-FXa activity reflects the apixaban blood concentration; however, measurement of this activity is both time-consuming and expensive. The current study aimed to evaluate the usefulness of routinely measured coagulation indices as future indicators of the efficacy and safety of apixaban.
Methods: Eighteen nonvalvular atrial fibrillation patients administered apixaban (average, 52.5 days) were prospectively enrolled in our hospital. The prothrombin time (PT) and the activated partial thromboplastin time (APTT) were measured by using the Coagpia (R) Reagent kits.
Results: The PT and the APTT increased significantly after the administration of apixaban (PT: p < 0.001, APTT: p < 0.001). While the apixaban plasma concentration by evaluating anti-FXa activity was not significantly correlated with the APTT after administration of apixaban, the concentration closely correlated with the PT (beta = 0.765, p < 0.001) and the percentage change in the PT from before and after the administration of apixaban (beta = 0.650, p = 0.005).
Conclusion: The usefulness of routinely monitoring PT in patients administered apixaban during the ordinary clinical medicine should be investigated further by large clinical trials.

• 出版日期2018-6