Nickel-Catalyzed Highly Chemo-, Regio-, and Stereoselective Three-Component Reaction of Norbornene with Two Alkynes

作者:Ogata Kenichi*; Sugasawa Jun; Atsuumi Yuka; Fukuzawa Shin ichi
来源:Organic Letters, 2010, 12(1): 148-151.
DOI:10.1021/ol9025556

摘要

The first three-component reaction of norbornene with two alkynes leading to 1,5-enyne via C-H bond activation of terminal silylacetylene was achieved using a Ni(cod)(2)/phosphine catalyst. This reaction is applicable for various Internal alkynes and norbornene derivatives with high regio- and stereoselectivities.

  • 出版日期2010-1-1