Differences in extinction responding and reinstatement of methamphetamine-seeking behavior between Fischer 344 and Lewis rats

作者：Kruzich PJ^*; Xi JL

来源：Pharmacology Biochemistry and Behavior, 2006, 83(3): 391-395.

DOI：10.1016/j.pbb.2006.02.021

• methamphetamine
• self-administration
• inbred rats
• Fischer 344
• Lewis
• rat
• extinction
• reinstatement

Fischer 344 (F344) and Lewis (LEW) rats differ in a number of self-administration behaviors. Whether or not these strains differ in methamphetamine-primed reinstatement of extinguished responding is unknown. F344 and LEW rats were trained to self-administer intravenous (i.v.) methamphetamine (0.06 mg/kg) during daily 2-h limited access sessions for 14 days. Following methamphetamine self-administration, subjects underwent a minimum of 6 extinction sessions where responding on the previously active lever resulted in no programmed consequences. Following extinction sessions, we evaluated strain and dose dependency of methamphetamine-primed (0.06, 0.12, or 0.24mg/kg/i.v.) reinstatement of responding. All subjects received each dose once. Dosing order was determined by utilizing a within-subjects Latin square design. We found partial strain differences in daily methamphetamine self-administration. In addition, F344 rats responded significantly more during the first extinction session compared LEW rats. Last, the LEW rats demonstrated a heightened propensity to reinstate responding following methamphetamine priming injections compared to F344 rats: Our results suggest that genetic background influences differences in methamphetamine-seeking behaviors in rats.

• 出版日期2006-3
• 单位武汉科技大学