Atrial Septal Defect Coexistent with Sjogren's Syndrome

作者：Ahmad Farook; Sadiq Muhammad Athar^*; Chee Kok Han; Zuhdi Ahmad Syadi Mahmood; Ahmad Wan Azman Wan

来源：Journal of the College of Physicians and Surgeons Pakistan, 2014, 24(6): 441-443.

• Pulmonary hypertension
• Ostium secundum atrial septal defect
• Sjogren's syndrome

Pulmonary hypertension is frequently associated with atrial septal defect and various connective tissue disorders. This case describes a 74-year-old woman who presented with symptoms of heart failure and concomitant involvement of salivary glands and keratoconjunctivitis. An echocardiogram demonstrated ostium secundum atrial septal defect with left to right shunt and severe pulmonary hypertension. Laboratory investigations confirmed the diagnosis of Sjogren's syndrome (SS) with positive anti-nuclear factor and centromere SS-A/Ro pattern. Anti-Ro (SS-A) was found positive. Atrial septal defect was Closed through transcatheter route with significant improvement in clinical outcome. This case report suggests a possible association of atrial septal defect with primary Sjogren's syndrome in an adult patient.

• 出版日期2014-6