A Subpathway-Based Method of Drug Reposition for Polycystic Ovary Syndrome

作者：Liu, Hai-Ying^*; Liu, Jian-Qiao; Mai, Zi-Xin; Zeng, Yan-Ting

来源：Reproductive Sciences, 2015, 22(4): 423-430.

DOI：10.1177/1933719114542025

• polycystic ovary syndrome
• drug reposition
• subpathway

The need for development of new therapeutic agents for polycystic ovary syndrome (PCOS) is urgent due to general lack of efficient and specialized drugs currently available. We aimed to explore the metabolic mechanism of PCOS and inferred drug reposition for PCOS by a subpathway-based method. Using the GSE34526 microarray data from the Gene Expression Omnibus database, we first identified the differentially expressed genes (DEGs) between PCOS and normal samples. Then, we identified 13 significantly enriched metabolic subpathways that may be involved in the development of PCOS. Finally, by an integrated analysis of PCOS-involved subpathways and drug-affected subpathways, we identified 54 novel small molecular drugs capable to target the PCOS-involved subpathways. We also mapped the DEGs of PCOS and a potential novel drug (alprostadil) into purine metabolism pathway to illustrate the potentially active mechanism of alprostadil on PCOS. Candidate agents identified by our approach may provide insights into a novel therapy approach for PCOS.

• 出版日期2015-4
• 单位广州医科大学