Association between polymorphisms in leptin, leptin receptor, and beta-adrenergic receptor genes and bone mineral density in postmenopausal Korean women

作者：Lee Hee Jun; Kim Hoon; Ku Seung Yup; Choi Young Min; Kim Jong Hak; Kim Jung Gu

来源：Menopause-The Journal of the North American Menopause Society, 2014, 21(1): 67-73.

DOI：10.1097/gme.0b013e31829366ed

• Bone density
• Leptin
• beta-Adrenergic receptor
• Polymorphism
• Bone markers

Objective: The purpose of this study was to investigate the association between single nucleotide polymorphisms in leptin (LEP), leptin receptor (LEPR), and beta-adrenergic receptor (ADRB) genes and bone mineral density (BMD) in postmenopausal Korean women. %26lt;br%26gt;Methods: LEP c.280G%26gt;A, LEPR c.326A%26gt;G, LEPR c.668A%26gt;G, LEPR c.1968G%26gt;C, LEPR c.2096C%26gt;T, ADRB2 c.46A%26gt;G, ADRB2 c.79C%26gt;G, ADRB2 c.718T%26gt;C, ADRB2 c.741G%26gt;T, ADRB2 c.769G%26gt;A, and ADRB3 c.190T%26gt;C polymorphisms were analyzed in 592 postmenopausal Korean women. Serum levels of leptin, soluble leptin receptor, osteoprotegerin, soluble receptor activator of the nuclear factor-kappa B ligand, bone alkaline phosphatase, and carboxy-terminal telopeptide of type I collagen were measured, and BMDs at the lumbar spine and femoral neck were also examined. %26lt;br%26gt;Results: Among the polymorphisms measured, only the LEPR c.1968G%26gt;C polymorphism was found to be associated with BMD at the femoral neck, and higher BMD was observed with increasing number of G alleles (P = 0.04). Osteoporosis at the femoral neck was 3.27 and 3.89 times more frequently observed in the AG and GG genotypes than in the AA genotype in the ADRB2 c.46A%26gt;G polymorphism (P = 0.024 and P = 0.015, respectively). However, no significant differences in serum levels of leptin, soluble leptin receptor, free leptin index, osteoprotegerin, soluble receptor activator of the nuclear factor-kappa B ligand, and bone turnover markers were detected among single and haplotype genotypes. %26lt;br%26gt;Conclusions: These results suggest that the LEPR c.1968G%26gt;C polymorphism may be one of the genetic factors affecting femoral neck BMD in postmenopausal Korean women and that an analysis of the ADRB2 c.46A%26gt;G polymorphism may be useful in identifying women at risk for osteoporosis at the femoral neck.

• 出版日期2014-1