Neurofilament heavy subunit in cerebrospinal fluid: A biomarker of amyotrophic lateral sclerosis?

作者：Mendonca Deise M F; Martins Sheila C S; Higashi Rafael; Muscara Marcelo N; Moura Neto Vivaldo; Chimelli Leila; Martinez Ana Maria B^*

来源：Amyotrophic Lateral Sclerosis, 2011, 12(2): 144-147.

DOI：10.3109/17482968.2010.542002

• Amyotrophic Lateral Sclerosis
• cerebrospinal fluid
• proteinopathy
• protein aggregation and neurofilament

The objectives of this study were to investigate the presence of the three neurofilament subunits, ubiquitin, proteasome and 3-nitrotyrosine, in CSF samples of ALS patients. CSF samples were obtained by lumbar puncture from 10 ALS patients and six controls. All samples were analysed by Western blotting. Results revealed that neurofilament heavy subunit was identified in 70% of ALS cases and we conclude that this subunit may be a promising biomarker for clinical diagnosis of ALS.

• 出版日期2011-3