New mutations of Nogo-C in hepatocellular carcinoma

作者：Chen Yicun; Tang Xiaojun; Zhang Xiran^*; Zhuang Linyuan

来源：Molecular Biology Reports, 2009, 36(2): 377-380.

DOI：10.1007/s11033-007-9190-3

• Nogo-C
• Hepatocellular carcinoma
• Point mutation

The neurite outgrowth inhibitor Nogo has attracted great interest, but its relevance with hepatocellular carcinoma has not been reported. This paper first found mutations of Nogo-C in HCC patients from Qidong in China: A172G (Thr58Ala), A340G (Arg114Gly), A571G (Ile191Val). In six examined patient cases from Qidong, the mutations occurred in five cases. The mutation Arg114Gly was predicted bioinformatically to affect Nogo-66 dimensional structure of Nogo-C. Our previous works also had indicated that mutant Nogo-C promoted liver cancer cell line apoptosis and resulted in molecular marker of HCC p53 gene transfer from nucleus to cytoplast. Above results revealed a new physiological role and clinical implications of Nogo-C on HCC.

• 出版日期2009-2
• 单位中国林业科学研究院; 南京大学; 南京师范大学; 中国林业科学研究院亚热带林业研究所