Antifungal saponins from bulbs of garlic, Allium sativum L. var. Voghiera

作者：Lanzotti Virginia^*; Barile Elisa; Antignani Vincenzo; Bonanomi Giuliano; Scala Felice

来源：Phytochemistry, 2012, 78: 126-134.

DOI：10.1016/j.phytochem.2012.03.009

• Alliaceae
• Garlic
• Saponins
• Voghierosides A-E
• Phenols
• Eugenol
• Antifungal activity

A bioassay-guided phytochemical analysis of the polar extract from the bulbs of garlic. Allium sativum L., var. Voghiera, typical of Voghiera, Ferrara (Italy), allowed the isolation of ten furostanol saponins; voghieroside Al/A2 and voghieroside B1/132, based on the rare agapanthagenin aglycone; voghieroside C1/C2, based on agigenin aglycone; and voghieroside D1/D2 and E1/E2, based on gitogenin aglycone. In addition, we found two known spirostanol saponins, agigenin 3-0-trisaccharide and gitogenin 3-0-tetrasaccharide. The chemical structures of the isolated compounds were established through a combination of extensive nuclear magnetic resonance, mass spectrometry and chemical analyses. High concentrations of two eugenol diglycosides were also found for the first time in Allium spp. The isolated compounds were evaluated for their antimicrobial activity towards two fungal species, the air-borne pathogen Botrytis cinerea and the antagonistic fungus Trichoderrna harzianum.

• 出版日期2012-6
• 单位河北医科大学