Direct Preparation of Trifluoromethylindium Reagents from Trifluoromethyl Iodide: Effective Trifluoromethylation and Perfluoroalkylation Reagents

作者：Fujiu Motohiro; Nakamura Yuzo; Serizawa Hiroki; Aikawa Kohsuke; Ito Shigekazu; Mikami Koichi^*

来源：European Journal of Organic Chemistry, 2012, (36): 7043-7047.

DOI：10.1002/ejoc.201201116

• Indium
• Fluorine
• Ferrocene
• Lithium
• Alkylation

The direct synthesis of trifluoromethylindium reagents prepared from trifluoromethyl iodide by using just one equivalent each of indium, lithium chloride or sodium iodide, and ferrocene is reported. The weak In center dot center dot center dot F interaction is suitable to prepare stable but nucleophilic perfluoroalkyl reagents, which were successfully employed in the perfluoroalkylation of aldehydes. Notably, the nucleophilic trifluoromethylation of various aldehydes took place with trifluoromethyl iodide by utilizing just one equivalent each of indium, lithium chloride, and ferrocene.

• 出版日期2012-12