A modular approach to a new class of monodentate chiral phosphorus ligands and their application in enantioselective copper-catalysed conjugate additions of diethylzinc to cyclohexenone

作者：Monti C^*; Gennari C; Steele RM; Piarulli U

来源：European Journal of Organic Chemistry, 2004, (16): 3557-3565.

DOI：10.1002/ejoc.200400227

• asymmetric catalysis
• P ligands
• copper
• Michael addition
• enones

A new family of chiral phosphorus ligands (5) for use in enantioselective catalysis have been synthesised. The ligands contain the electron-poor bis(sulfonyl)diazaphospholidine moiety and possess a highly modular structure which is well suited to the synthesis of a library. A small library (23 members) of ligands 5 was prepared and tested in the enantioselective copper-catalysed conjugate addition of diethylzinc to cyclohexenone. Complete conversions were obtained with enantiomeric excesses (ee) of up to 75%.

• 出版日期2004-8-13