Automated methods for the location of the boundaries of chromatographic peaks

作者：Stevenson Paul G; Gritti Fabrice; Guiochon Georges^*

来源：Journal of Chromatography A, 2011, 1218(45): 8255-8263.

DOI：10.1016/j.chroma.2011.08.088

• Automated data analysis
• Column efficiency
• First peak moment
• Peak area
• Peak boundaries
• Second peak moment

Several simple techniques are presented for the identification of the boundaries of chromatographic peaks. These methods provide a significant reduction in the time needed to perform the rapid, automatic calculation of the central peak moments and to evaluate the quality of a separation while improving the accuracy of the measurements of column efficiencies. It was found that the identification of the peak boundaries as functions of the peak widths and the examination of the slope of the signal to noise versus time plot are viable alternatives to a manual determination.

• 出版日期2011-11-11