Anti-hemorrhagic effect of hydro-alcoholic extract of the leaves of Mikania glomerata in lesions induced by Bothrops jararaca venom in rats

作者：Mourao Vanessa Barreto; Giraldi Gleice Mara; Grosso Neves Lia Mara; de Gaspari de Gasp Fernanda Oliveira; Ferreira Rodrigues Rodney Alexandre; Alves Armindo Antonio; Marreto Esquisatto Marcelo Augusto; Mazzi Mauricio Ventura; Sampaio Mendonca Fernanda Aparecida; Tech dos Santos Glaucia Maria

来源：Acta Cirurgica Brasileira, 2014, 29(1): 30-37.

DOI：10.1590/s0102-86502014000100005

• Snake venons
• Plants, Medicinal
• Mikania
• Bothrops
• Rats

PURPOSE: To investigate the effects of hydroalcoholic leaf extract of Mikania glomerata Spreng (Asteraceae) on the activity of Bothrops jararaca snake venom in Wistar rats.
METHODS: Fifty four rats Wistar were divided into six groups of nine animals in each: control treated with saline; control treated with B. jararaca venom; control treated with M. glomerata extract; B. jararaca venom incubated with M. glomerata extract at proportions of 1:1, 1:2, and 1:4.
RESULTS: Histopathological and morphometric analysis showed that intradermal administration of snake venom incubated with the hydroalcoholic extract at proportions of 1:1, 1:2 and 1:4 promoted a significant reduction in the number of inflammatory cells and a marked decrease in edema after the third hour. There was also a significant reduction in the intensity of the hemorrhagic halo in animals receiving the snake venom incubated with the extract, with the observation of a progressive and parallel inhibition with increasing proportion of M. glomerata.
CONCLUSION: The Mikania glomerata hydroalcoholic extract exerted effective anti-inflammatory and antihemorrhagic activity against the effects induced by Bothrops jararaca snake venom.

• 出版日期2014-1