Nephronectin Expression Is Up-Regulated by BMP-2

作者：Kurosawa Tamaki; Yamada Atsushi^*; Suzuki Dai; Morimura Naoko; Sasagane Yoshiyuki; Itabe Hiroyuki; Kamijo Ryutaro

来源：Biological & Pharmaceutical Bulletin, 2016, 39(7): 1211-1215.

DOI：10.1248/bpb.b15-00941

• nephronectin
• bone morphogenetic protein-2
• C2C12
• SMAD signaling pathway

Nephronectin (Npnt), known to be a ligand of integrin AM, plays important roles in the development and function of various tissues, including those of the kidneys, liver, bones, and muscles. In previous studies, we showed that the expression of Npnt mRNA was regulated by various cytokines, including transforming growth factor-beta (TGF-beta), tumor necrosis factor-alpha (TNF-alpha), and oncostatin M (OSM), and that over-expression of Npnt enhanced osteoblast differentiation. In this study, we found that bone morphogenic protein-2 (BMP-2), known as an osteogenesis inducing cytokine, strongly up-regulated the expression of Npnt mRNA in a murine skeletal muscle cell line (C2C12) via the BMP-SMAD signaling pathway.

• 出版日期2016-7