Association of Osteopontin Gene Polymorphisms with Colorectal Cancer

作者：Kamal Asmaa^*; Darwish Rania Kamal; Saad Samar; Salama Mohamed; El Baradie Tarek S; Mahmoud Heba G M; Elshiwy Yasmine

来源：Cancer Investigation, 2017, 35(2): 71-77.

DOI：10.1080/07357907.2016.1247454

• Osteopontin
• Colorectal cancer
• Gene polymorphism
• OPN rs1126616
• OPN rs9138

We investigated the association of the Osteopontin (OPN) (rs9138 and rs1126616) polymorphisms with colorectal cancer (CRC). One hundred CRC patients and 112 healthy individuals were subjected to OPN (rs9138 and rs1126616) genotyping and measurement of OPN protein plasma level. The C allele of OPN rs1126616 and the CC haplotype were significantly higher in CRC patient (p = 0.036, 0.003, respectively). In females, the C allele of OPN rs9318 (A/C) polymorphism was significantly associated with increased CRC risk (p = 0.036). The plasma OPN level >104.35ng/mL was significantly associated with CRC. Our findings suggest a significant role played by OPN (rs9138 and rs1126616) in colorectal carcinogenesis.

• 出版日期2017