Mullinamides A and B, new cyclopeptides produced by the Ruth Mullins coal mine fire isolate Streptomyces sp RM-27-46

作者：Wang Xiachang; Shaaban Khaled A; Elshahawi Sherif I; Ponomareva Larissa V; Sunkara Manjula; Copley Gregory C; Hower James C; Morris Andrew J; Kharel Madan K^*; Thorson Jon S

来源：Journal of Antibiotics, 2014, 67(8): 571-575.

DOI：10.1038/ja.2014.37

• antibiotic
• bioprospecting
• cyclopeptide
• natural product
• pharmacognosy
• surugamide

Two new cyclopeptides, mullinamides A [cyclo-(-L-Gly-L-Glu-L-Val-L-IIe-L-Pro-)] and B [cyclo-(-L-Glu-L-Met-L-Pro-)] were isolated from the crude extract of terrestrial Streptomyces sp. RM-27-46 along with the three known cyclopeptides surugamide A [cyclo-(-L-Ile-D-Ile-L-Lys-L-Ile-D-Phe-D-Leu-L-Ile-D-Ala-)], cyclo-(-L-Pro-L-Phe-) and cyclo-(-L-Pro-L-Leu-). The structures of the new compounds were elucidated by the cumulative analyses of NMR spectroscopy and HRMS. Although mullinamides A and B displayed no appreciable antimicrobial/fungal activity or cytotoxicity, this study highlights the first reported antibacterial activity of surugamide A.

• 出版日期2014-8