An improved palladium(II)-catalyzed method for the synthesis of aryl ketones from aryl carboxylic acids and organonitriles

作者：Axelsson Linda; Veron Jean Baptiste; Savmarker Jonas; Lindh Jonas; Odell Luke R; Larhed Mats^*

来源：Tetrahedron Letters, 2014, 55(15): 2376-2380.

DOI：10.1016/j.tetlet.2014.02.109

• Palladium
• Nitrile
• Aryl ketone
• Decarboxylation
• Flow chemistry

A palladium(II)-catalyzed decarboxylative protocol for the synthesis of aryl ketones has been developed. The addition of TFA was shown to improve the reaction yield and employing THF as solvent enabled the use of solid nitriles and in only a small excess. Using this method, five different benzoic acids reacted with a wide range of nitriles to produce 29 diverse (hetero)aryl ketone derivatives in up to 94% yield.

• 出版日期2014-4-9