The effect of antenatal steroid treatment on fetal autonomic heart rate regulation revealed by fetal magnetocardiography (fMCG)

作者：Schneider Uwe^*; Fiedler Anja; Schroeder Beatrix; Jaekel Susann; Stacke Angelika; Hoyer Dirk; Schleussner Ekkehard

来源：Early Human Development, 2010, 86(5): 319-325.

DOI：10.1016/j.earlhumdev.2010.05.018

• Prenatal diagnosis
• Steroid administration
• Heart rate variability
• Autonomic nervous system
• Fetal development

Background: Steroid administration to accelerate fetal lung maturation reduces neonatal morbidity and mortality in the case of preterm delivery. Behavioral observations suggest effects on fetal cardiovascular regulation.
Aim: We hypothesize that beat to beat heart rate variability (fHRV) derived from fetal magnetocardiography (fMCG) will reveal a direct, acute steroidal effect on fetal autonomic heart rate regulation.
Subjects: Eight patients between 29 and 34 weeks of gestation at risk for preterm birth who were treated with betamethasone (2 x 12 mg within 24 h).
Study design: Subjects were studied prior to the first and within 6 h after the second administration. Continuous fMCG was recorded with a 31-channel-SQUID biomagnetometer. Each dataset was processed by subtracting maternal cardiac artefacts and determining the time instants of the fetal heart beats. fHRV analysis was applied to periods of fetal quiescence of 4 min length.
Outcome measures: We compared fHRV prior versus post steroid administration.
Results: Steroid exposure reduced all parameters of overall fHRV significantly. The fHRV parameters representing short term variability remained unaffected. Mean fetal heart rate significantly decreased. The complexity of the heart rate patterns increased.
Conclusion: Our results suggest an acute shift in the symptaho-vagal balance of fetuses exposed to betamethasone in utero toward sympathetic suppression.

• 出版日期2010-5